Several studies have assessed the influence of a statin TI on economic and clinical outcomes from a health plan’s perspective. Korman and Borysiuk examined the influence of a TI from lovastatin to pravastatin within a Veterans Affairs (VA) population

pharmacy benefit managers (PBMs) and health plans to pursue various cost-control methods and interventions, including therapeutic interchange (TI). The practice of TI relies on the conversion of one drug to a different drug within the same therapeutic class to reduce the cost of drug therapy without compromising therapeutic efficacy or safety. More than 50% of employers reported the use of TI in each of the years from 2000 to 2002, and about 50% of Medicaid managed care organizations (MCOs) reported the use of TI in 2002 to 2004. The clinically similar effectiveness and side effect profiles of statins, coupled with their frequent use and high costs, make the statin class ideal for TI. Several studies have assessed the influence of a statin TI on economic and clinical outcomes from a health plan’s perspective. Korman and Borysiuk examined the influence of a TI from lovastatin to pravastatin within a Veterans Affairs (VA) population ABSTRACT